E-EPA reduces cardiovascular disease risk factors in diabetics
cholesterol and triglycerides, plasma cholesteryl ester transfer protein (CETP) activity, LDL cholesterol subfractions, and C-reactive protein were measured before and after the treatment regimen.
At the conclusion of the study, serum EPA levels were elevated while arachidonic acid levels were decreased in the group that received E-EPA. In other words, the AA/EPA ratio improved. Remnant lipoprotein triglycerides, CETP activity, small dense LDL, and CRP levels were significantly lowered in the group that received EPA compared to the group treated by diet alone. Decreases in in CRP were correlated with reductions in remnant lipoprotein cholesterol and small dense LDL.
“The present study is the first to demonstrate that purified EPA reduces sdLDL, remnants, and CRP, thereby potentially leading to the reduction in development of atherosclerosis and CVD in metabolic syndrome,” the authors conclude.
Cite: Satoh N, Shimatsu AS, Kotani, K et al. Purified Eicosapentaenoic Acid Reduces Small Dense LDL, Remnant Lipoprotein Particles, and C-rective Protein in Metabolic Syndrome Diabetes Care 2007;30: 144-146
Resource: Dr. Matti Tolonen